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Mindfulness-based Stress Reduction (MBSR) Program: the Effect of a Novel Psycho-interventional Method on Quality of Life, Mental Health, and Self-efficacy in Female Patients with Multiple Sclerosis: A Randomized Clinical Trial
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  • 1 Department of Psychology, University of Tehran, Tehran, Iran
  • 2 Neurology group, Department of Regenerative Biomedicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  • 3 Neurology group, Faculty of Medicine, Huston University, Huston, Texas, UnitedStatesofAmerica
  • 4 Department of Clinical Research, Tehran University of Medical Sciences, Tehran Heart Center, Tehran, Iran
  • Correspondence should be addressed to Shima Haghani, Department of Clinical Research, Tehran University of Medical Sciences, Tehran Heart Center, Tehran, Iran; Tel: ; Fax: ; Email: sh_haghani1@yahoo.com1.


Multiple sclerosis (MS) is a disease of central nervous system affecting young population. Burden of the disease, lifelong confrontation with a complex disease with no cure and the need for continuous care lead to chronic stress in patients and their caregivers. Mindfulness stress reduction, as a novel psycho intervention method, might be helpful in MS patients to reduce this chronic stress. A group of female patients diagnosed with definite MS (According to MC Donald criteria 2010 by a neurologist) were randomized to either an immediate MBSR program (n=12) or waitlist (n=12). The intervention consisted of a weekly MBSR group lasting 2.5 hours for 8 weeks plus a 6 hours retreat. Patients completed questionnaires pre- and post- intervention or waitlist period. Preliminary analysis revealed that there was no significant improvement in physical symptoms and mental health (p>0.05). However, a significant improvement was observed in patients' quality of life (p>0.05). These re-sults provide preliminary evidence for the feasibility and efficacy of MBSR intervention as a novel psychotherapeutic method for improving quality of life in patients with MS.


Mindfulness Based Stress Reduction (MBSR), Multiple sclerosis (MS), Quality of life, Mental health, Self-efficacy

  • * This paper has been published in Volume 6, 2017, Issue 11, Pages: 211-215
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