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Serum E-selectin in Preeclampsia: A Case – Control Study
(Research (Original))
  • 1 Department of Hematopathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , Iran
  • 2 Department of Obstetrics and Gynecology, Women's Health Research Center,Mashhad University of Medical Sciences, Mashhad , Iran
  • 3 Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , Iran
  • 4 Vali-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Correspondence should be addressed to Malihe Afiat, Department of Obstetrics and Gynecology, Women's Health Research Center,Mashhad University of Medical Sciences, Mashhad , Iran; Tel: ; Fax: ; Email: afiatm@mums.ac.ir.

Abstract

Preeclampsia (PE) is an important disease in pregnancy, and is one of the causes of maternal morbidity, mortality and adverse neonatal outcomes. One of the basic pathophysiologies of preeclampsia is endothelial cell dysfunction as suggested by an elevated concentration of endothelin-selectin. The aim of this study was to compare the sera levels of endothelin-selectin (E-selectin) in normal and pre-eclamptic term pregnancy. This case-control study was followed on 80 patients admitted to the Departments of Obstetrics and Gynecology of the Ghaem and Emam Reza hospitals in Mashhad University of Medical Sciences. The Control group consisted of 40 normal term pregnant women (≥ 37 weeks) and the Case group was 40 term preeclamptic pregnant women. Participants were enrolled after approval by the ethics committee and received the informed consent. E-selectin concentration evaluated in two groups. The level of E-selectin was significantly in two groups. It was higher in sera of pre-eclamptic patients than the normal pregnancy (p=0.0001). Especially, it was significantly higher in severe pre-eclamptic patients (p<0.05). In conclusion, the found results showed that E-selectin was increased in term of PE that and may be useful for predicting the severity of pre-eclampsia.

Keywords

Preeclampsia, Cell adhesion molecules, E-selectin

  • * This paper has been published in Volume 7, 2018, Issue 1, Pages: 16-19
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